ROLE OF THE COMBINATION OF CYCLIN-DEPENDENT KINASE INHIBITORS (CDKI) AND RADIOTHERAPY (RT) IN THE TREATMENT OF METASTATIC BREAST CANCER (MBC): ADVANTAGES AND RISKS IN CLINICAL PRACTICE

Targeting cell cycle has become the gold standard for metastatic breast cancer (MBC), being cyclin-dependent kinase inhibitors (CDKIs) cornerstones of its treatment, alongside radiotherapy (RT).To date, no definite Sex machines evidence regarding safety and efficacy of the combination of CDKIs plus radiotherapy (RT) is currently available.Purpose o

With the emergence of various developments in determining pathophysiology behind diseases, emergence of resistance against diseases and to utilize drugs for the long-term effects, and the need to design an effective treatment against most common infectious and non-infectious diseases, the need of developing more effective drug comes under the limel

Aqueous leachates prepared from natural antibacterial clays, arbitrarily designated CB-L, release metal ions into suspension, have a low pH (3.4-5), generate reactive oxygen species (ROS) and H2O2, Quarter Zip and have a high oxidation-reduction potential.To isolate the role of pH in the antibacterial activity of CB clay mixtures, we exposed three

Sex machines Abstract Background The rarity of juvenile psammomatoid ossifying fibroma (JPOF) and lack of cytogenetic studies prompted us to report a novel SETD2 gene mutation in a benign odontogenic tumour.Case presentation A 21-year-old man presented with a hard, expanded mandibular cortex.Computed tomography revealed multilocular radiopacity in